Salmonella enterica serovar typhimurium productively infects human primary trophoblast cells and induces inflammatory cell death

Download
  1. Get@NRC: Salmonella enterica serovar typhimurium productively infects human primary trophoblast cells and induces inflammatory cell death (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/j.placenta.2014.06.203
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Proceedings titlePlacenta
ConferenceInternational Federation of Placental Associations Conference (IFPA EPG 2014), Sept 9-12, 2014, Paris, France
ISSN0143-4004
Volume35
Issue9
PagesA62A63
AbstractSalmonella enterica species are intracellular pathogens causative agents of gastroenteritis and typhoid fever in humans worldwide. Pregnancy poses an increased risk of severe Salmonellosis in many mammalian species contributing to miscarriage and maternal illness. Previous studies have indicated that Salmonella enterica Typhimurium (S. Tm) rapidly replicates within murine placenta leading to placental inflammation and death. Furthermore, IL-10 production by human choriocarcinoma trophoblast cells was shown to delay phagosomal maturation facilitating intracellular pathogen replication. The objective of this study was to evaluate the potential vulnerability of human primary trophoblast cells (TBCs) to S. Tm infection and elucidate the mechanism of cell death and inflammation.
Publication date
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
NRC numberNRC-HHT-53247
NPARC number21275377
Export citationExport as RIS
Report a correctionReport a correction
Record identifier00753805-a34d-405e-baaf-7d287ae2e3dd
Record created2015-06-17
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)
Date modified: