The structure of the polysaccharide of the lipopolysaccharide produced by Taylorella equigenitalis type strain (ATCC 35865): Carbohydr.Res.

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TypeArticle
Journal titleCarbohydr.Res.
Volume343
Issue18
Pages30793084; # of pages: 6
SubjectACID; Acids; analysis; ANTIGEN; Antigens; Bacteria; bacterial; Bacterial Vaccines; biosynthesis; Canada; Carbohydrate Sequence; chemistry; COMPONENT; core oligosaccharide; DISACCHARIDE; Electrophoresis,Polyacrylamide Gel; Gram Negative Bacteria; Gram-Negative Bacteria; Humans; IDENTIFICATION; Immune Sera; immunology; INFECTION; isolation & purification; linear; LIPOPOLYSACCHARIDE; Lipopolysaccharides; LPS; Magnetic Resonance Spectroscopy; metabolism; Molecular Sequence Data; MS; NMR; O antigen; O Antigens; O-antigen; oligosaccharide; POLYSACCHARIDE; Serum; Species Specificity; Spectrometry,Mass,Electrospray Ionization; STRAIN; structure; Taylorella equigenitalis; UNIT; Vaccines
AbstractTaylorella equigenitalis is a Gram-negative bacterium that causes venereally transmitted contagious equine metritis (CEM), and its identification and differentiation from other bacteria and Taylorella species is an important requirement for the control of CEM infection. Based on the results of NMR and MS analysis, the antigenic O-polysaccharide (O-PS) component of the lipopolysaccharide (LPS) produced by the type strain T. equigenitalis (ATCC 35865) was found to be a linear polymer composed of a repeating disaccharide unit, containing partially amidated 2,3-diacetamido-2,3-dideoxy-alpha-L-guluronic and 2,3-diacetamido-2,3-dideoxy-beta-D-mannuronic acids, terminated with a 4-O-methylated non-reducing Gulp-NAc3NAcA residue, and has the structure [structure: see text]. The O-PS of the type strain T. equigenitalis LPS provides a specific antigenic marker for the discrimination of the pathogen from the related type strain of T. asinigenitalis sp. nov, a phenotypically indistinguishable non-pathogenic bacterium having a serologically and structurally unrelated LPS O-antigen. The analysis of a structurally unusual core oligosaccharide of the LPS is also reported
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberVINOGRADOV2008
NPARC number9362115
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Record identifier0119ef51-f4ca-44c9-8f8b-405939fd54f0
Record created2009-07-10
Record modified2016-05-09
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