Nitric oxide inhibitory isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia

Download
  1. Get@NRC: Nitric oxide inhibitory isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1021/np020455x
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume66
Issue2
Pages255258; # of pages: 4
AbstractA methanolic extract of Orthosiphon stamineus yielded six new highly oxygenated isopimarane-type diterpenes, orthosiphols U-Z (1-6), and 15 previously reported diterpenes. The isolated diterpenes all showed significant dose-dependent inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Orthosiphols A (7), B (8), D (9), and X (4) showed more potent inhibitory activities than a positive control, N(G)-monomethyl-l-arginine (l-NMMA), and 1 displayed the strongest activity with an IC(50) value of 6.4 microM.
Publication date
LanguageEnglish
Peer reviewedYes
NRC publication
This is a non-NRC publication

"Non-NRC publications" are publications authored by NRC employees prior to their employment by NRC.

NPARC number21274453
Export citationExport as RIS
Report a correctionReport a correction
Record identifier01c2e7ad-5d8c-44be-807c-73462ac87c2f
Record created2015-03-13
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)