Tularemia vaccines : recent develpments and remaining hurdles

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DOIResolve DOI: http://doi.org/10.2217/fmb.11.22
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TypeArticle
Journal titleFuture Microbiology
Volume6
Issue4
Pages391405; # of pages: 15
AbstractFrancisella tularensis subsp. tularensis is a facultative intracellular bacterial pathogen of humans and other mammals. Its inhaled infectious dose is very low and can result in very high mortality. Historically, subsp. tularensis was developed as a biological weapon and there are now concerns about its abuse as such by terrorists. A live attenuated vaccine developed pragmatically more than half a century ago from the less virulent holarctica subsp. is the sole prophylactic available, but it remains unlicensed. In recent years several other potential live, killed and subunit vaccine candidates have been developed and tested in mice for their efficacy against respiratory challenge with subsp. tularensis. This article will review these vaccine candidates and the development hurdles they face.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number19230301
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Record identifier039ac874-a1a6-4c69-ba31-51d911a50230
Record created2012-03-08
Record modified2016-05-09
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