Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence: Int.J.Med.Microbiol.

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TypeArticle
Journal titleInt.J.Med.Microbiol.
Volume297
Issue5
Pages297306; # of pages: 10
SubjectBacteria; bacterial; biosynthesis; chemistry; EXPRESSION; genetics; Gram Negative Bacteria; Gram-Negative Bacteria; Haemophilus; Haemophilus Infections; Haemophilus influenzae; HAEMOPHILUS-INFLUENZAE; HETEROGENEITY; Human; Humans; KDO; lipid; Lipid A; LIPID-A; LIPOPOLYSACCHARIDE; Lipopolysaccharides; LPS; Microbiology; MOLECULE; oligosaccharide; pathogenicity; Role; STRUCTURAL; structure; SUBSTITUENT; UNIT; Virulence; Virulence Factors
AbstractLipopolysaccharide (LPS) is a major virulence determinant of the human bacterial pathogen Haemophilus influenzae. A characteristic feature of H. influenzae LPS is the extensive intra- and inter-strain heterogeneity of glycoform structure which is key to the role of the molecule in both commensal and disease-causing behaviour of the bacterium. Through the combination of genetics and detailed structural analyses, H. influenzae is an exemplar Gram-negative bacterium for which now the most extensive and detailed LPS structural data and functional correlates are available. LPS from H. influenzae consists of a conserved glucose-substituted triheptosyl inner-core moiety l-alpha-d-Hepp-(1-->2)-[PEtn-->6]-l-alpha-d-Hepp-(1-->3)-[beta-d-Glcp-(1-- >4)]-l-alpha-d-Hepp linked to lipid A via Kdo 4-phosphate. The inner-core unit provides the template for attachment of oligosaccharide- and non-carbohydrate substituents. Here, the structure, genetics and expression of LPS glycoforms in the outer core are reviewed as well as their implication on virulence
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedNo
NRC numberSCHWEDA2007
NPARC number9360549
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Record identifier0504565e-9201-446e-b392-817f9997da00
Record created2009-07-10
Record modified2016-05-09
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