Constituents of the Vietnamese medicinal plant Streptocaulon juventas and their antiproliferative activity against the Human HT-1080 Fibrosarcoma cell line

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DOIResolve DOI: http://doi.org/10.1021/np030177h
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume66
Issue11
Pages14271433; # of pages: 7
AbstractThe methanolic extract of roots of Streptocaulon juventas, having shown strong antiproliferative activity against the highly metastatic human HT-1080 fibrosarcoma cell line, was subjected to activity-guided isolation to yield 16 cardenolides including five new ones, acovenosigenin A 3-O-β-digitoxopyranoside (1), digitoxigenin gentiobioside (2), digitoxigenin 3-O-[O-β-glucopyranosyl-(1→6)-O-β-glucopyranosyl-(1→4)-3-O-acetyl-β-digitoxopyranoside] (3), digitoxigenin 3-O-[O-β-glucopyranosyl-(1→6)-O-β-glucopyranosyl-(1→4)-O-β-digitalopyranosyl-(1→4)-β-cymaropyranoside] (4), and periplogenin 3-O-(4-O-β-glucopyranosyl-β-digitalopyranoside) (5), and two new hemiterpenoids, (4R)-4-hydroxy-3-isopropylpentyl β-rutinoside (6) and (R)-2-ethyl-3-methylbutyl β-rutinoside (7), together with two known phenylpropanoids and a known phenylethanoid. The isolated cardenolides strongly inhibited the proliferation of the HT-1080 cell line (IC50 values, 54−1600 nM).
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LanguageEnglish
Peer reviewedYes
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NPARC number21274316
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Record identifier051be649-9c6b-4874-b960-aa7b3c9d66c5
Record created2015-03-09
Record modified2016-05-09
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