Characterization of L-Digitoxosyl-phenanthroviridin from Streptomyces venezuelae ISP5230

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DOIResolve DOI: http://doi.org/10.1021/acs.jnatprod.5b00277
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
Volume78
Issue8
Pages19421948; # of pages: 7
Subjectaglycone; daunorubicin; digitoxosyl phenanthroviridin; gyrase inhibitor; lysine; unclassified drug; absorption spectroscopy; amino acid metabolism; cancer cell culture; cytotoxicity; fermentation; heteronuclear multiple bond correlation; heteronuclear single quantum coherence; high performance liquid chromatography; human cell; liquid chromatography; mass spectrometry; nuclear Overhauser effect; protein structure; proton nuclear magnetic resonance; Streptomyces venezuelae; tandem mass spectrometry
AbstractThe jadomycin-derived compound l-digitoxosyl-phenanthroviridin was isolated from fermentations of Streptomyces venezuelae ISP5230 grown in nutrient-deficient media with l-lysine as the sole nitrogen source. Structural elucidation was accomplished using a combination of high-resolution MS, LC-MS/MS, and 1D- and 2D-NMR. The compound was evaluated against the National Cancer Institute (NCI) 60 human tumor cell line screen in both the one-dose and five-dose screens, and cytotoxicity was compared to a small library of jadomycin analogues to probe the structure-activity relationship.
Publication date
PublisherAmerican Chemical Society
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); Aquatic and Crop Resource Development
Peer reviewedYes
NPARC number21277038
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Record identifier060c5f22-ee41-4fc5-8909-9e451dc156ac
Record created2015-11-10
Record modified2016-05-09
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