The human serum metabolome

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DOIResolve DOI: http://doi.org/10.1371/journal.pone.0016957
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TypeArticle
Journal titlePLoS ONE
ISSN1932-6203
Volume6
Issue2
Article numbere16957
Subjectlipids; fatty acids; lipid metabolism; nuclear magnetic resonance; blood plasma; lipid mediators; Gas Chromatography-Mass Spectrometry; metabolomics
AbstractContinuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 confirmed and highly probable human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca. © 2011 Psychogios et al.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); National Institute for Nanotechnology
Peer reviewedYes
NPARC number21272044
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Record identifier06202037-dca0-4a34-a928-d32a22c0eafd
Record created2014-05-23
Record modified2016-05-09
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