The study of the core part and non-repeating elements of the O-antigen of Brucella lipopolysaccharide

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DOIResolve DOI: http://doi.org/10.1016/j.carres.2012.11.004
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TypeArticle
Journal titleCarbohydrate Research
ISSN0008-6215
Volume366
Pages3337; # of pages: 5
SubjectBrucella; Core part; Host-cell invasion; Human pathogens; Immune systems; Intracellular survival; Lipopolysaccharides; Low toxicity; LPS; MS; O-Antigen; Reducing ends; Spectroscopic method; Virulence factors; Nuclear magnetic resonance; Organic compounds; Structure (composition); Synthesis (chemical); Spectroscopic analysis; lipopolysaccharide; O antigen; antimicrobial activity; article; Brucella; chemical analysis; immune system; nonhuman; priority journal; spectroscopy; structure analysis; Animalia; Brucella
AbstractBrucella is an animal and human pathogen that expresses several virulence factors required for host cell invasion and intracellular survival. It produces LPS with unusually low toxicity, which hampers the detection of bacteria by the host immune system and thus provides resistance against intracellular antimicrobial mechanisms of the host. By chemical and spectroscopic methods we determined the structure of the LPS core and of a non-repetitive oligosaccharide fragment at the reducing end of the O-specific polysaccharide. These data should be useful for understanding the biological role of the Brucella LPS. Crown Copyright © 2012 Published by Elsevier Ltd. All rights reserved.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21270668
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Record identifier0630e6b2-d834-48ff-ae1a-62b437312723
Record created2014-02-17
Record modified2016-05-09
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