Assessing demyelination and remyelination in mouse brain by near-infrared spectroscopy

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DOIResolve DOI: http://doi.org/10.1007/978-94-011-0371-8_222
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TypeBook Chapter
Proceedings titleSpectroscopy of Biological Molecules
Conference6th European Conference on the Spectroscopy of Biological Molecules, September 3-8, 1995, Villeneuve d’Ascq, France
ISSN978-94-010-4166-9
978-94-011-0371-8
Pages485486; # of pages: 2
AbstractDemyelination is the process by which the myelin sheath wrapping nerve axons in white matter is degraded, disrupting the conduction of nerve impulses. This destructive course occurs in multiple sclerosis (MS), causing paralysis, blindness and muscle weakness. We have previously demonstrated the potential use of IR spectroscopy in characterising healthy and MS diseased autopsy tissue.1 We have now extended our studies using an animal model of demyelination (as in MS) and remyelination (as in individuals undergoing remission) to characterize brain tissue at the various stages of the disease process and to explore the possibility of assessing these conditions in-vivo with the use of near-infrared (NIR) spectroscopy.
Publication date
PublisherSpringer Netherlands
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedNo
NRC number420
NPARC number9147775
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Record identifier0810ce2b-3c23-4d73-8080-6140bd07150d
Record created2009-06-25
Record modified2016-11-21
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