A key role of microRNA-29b for the suppression of colon cancer cell migration by American ginseng

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DOIResolve DOI: http://doi.org/10.1371/journal.pone.0075034
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TypeArticle
Journal titlePLoS ONE
ISSN1932-6203
Volume8
Issue10
Article numbere75034
Subjectgelatinase A; hexane; microRNA 29b; Panax quinquefolius extract; plant extract; unclassified drug; antineoplastic activity; article; cancer inhibition; cell migration; colon cancer; human; human cell; molecular mechanics; nonhuman; Panax quinquefolius; protein function; protein targeting; regulatory mechanism
AbstractMetastasis of colon cancer cells increases the risk of colon cancer mortality. We have recently shown that American ginseng prevents colon cancer, and a Hexane extract of American Ginseng (HAG) has particularly potent anti-inflammatory and anti-cancer properties. Dysregulated microRNA (miR) expression has been observed in several disease conditions including colon cancer. Using global miR expression profiling, we observed increased miR-29b in colon cancer cells following exposure to HAG. Since miR-29b plays a role in regulating the migration of cancer cells, we hypothesized that HAG induces miR-29b expression to target matrix metalloproteinase-2 (MMP-2) thereby suppressing the migration of colon cancer cells. Results are consistent with this hypothesis. Our study supports the understanding that targeting MMP-2 by miR-29b is a mechanism by which HAG suppresses the migration of colon cancer cells.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Institute for National Measurement Standards (INMS-IENM)
Peer reviewedYes
NPARC number21269795
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Record identifier08efc757-5631-4d93-8567-fdbfaec20db7
Record created2013-12-13
Record modified2016-05-09
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