Unexpected Superoxide Dismutase Antioxidant Activity of Ferric Chloride in Acetonitrile

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TypeArticle
Journal titleJournal Of Organic Chemistry
ISSN00223263
Volume68
Issue23
Pages91629165; # of pages: 4
AbstractThe azobis(isobutyronitrile)-initiated autoxidation of -terpinene in acetonitrile at 50 C yields only p-cymene and hydrogen peroxide (1:1) in a chain reaction carried by the hydroperoxyl radical, HOO (Foti, M. C.; Ingold, K. U. J. Agric. Food Chem. 2003, 51, 2758-2765). This reaction is retarded by very low (M) concentrations of FeCl3 and CuCl2. The kinetics of the FeCl3-inhibited autoxidation are consistent with chain-termination via the following: Fe3+ + HOO [FeIV-OOH]3+ and [FeIV-OOH]3+ + HOO Fe3+ + H2O2 + O2. Thus, FeCl3 in acetonitrile can be regarded as a very effective (and very simple) superoxide dismutase. The kinetics of the CuCl2-inhibited autoxidation indicate that chain transfer occurs and becomes more and more important as the reaction proceeds, i.e., the inhibition is replaced by autocatalysis. These kinetics are consistent withreduction of Cu2+ to Cu+ by HOO and then the reoxidation of Cu+ to Cu2+ by both HOO and the H2O2 product. The latter reaction yields HO radicals which continue the chain.
Publication date
Linkhttp://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/jo034908u
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier10008226
NPARC number12328587
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Record identifier09809f6b-ebd8-49c4-aa1b-1d6b8481c395
Record created2009-09-10
Record modified2016-05-09
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