Nonlinear optical microscopy in decoding arterial diseases

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DOIResolve DOI: http://doi.org/10.1007/s12551-012-0077-8
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TypeArticle
Journal titleBiophysical Reviews
Volume4
Issue4
Pages323334; # of pages: 12
SubjectAtherosclerosis; Nonlinear optical microscopy; Second-harmonic generation; Two-photon excited fluorescence; Coherent anti-Stokes Raman; Artery
AbstractPathological understanding of arterial diseases is mainly attributable to histological observations based on conventional tissue staining protocols. The emerging development of nonlinear optical microscopy (NLOM), particularly in second-harmonic generation, two-photon excited fluorescence and coherent Raman scattering, provides a new venue to visualize pathological changes in the extracellular matrix caused by atherosclerosis progression. These techniques in general require minimal tissue preparation and offer rapid three-dimensional imaging. The capability of label-free microscopic imaging enables disease impact to be studied directly on the bulk artery tissue, thus minimally perturbing the sample. In this review, we look at recent progress in applications related to arterial disease imaging using various forms of NLOM.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biodiagnostics; NRC Steacie Institute for Molecular Sciences
Peer reviewedYes
NPARC number21186085
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Record identifier09f20a48-1e98-4b86-9450-44c3b4bb2841
Record created2013-01-09
Record modified2016-05-09
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