Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?

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DOIResolve DOI: http://doi.org/10.1016/0003-9861(83)90145-5
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TypeArticle
Journal titleArchives of Biochemistry and Biophysics
ISSN0003-9861
Volume221
Issue1
Pages281290; # of pages: 10
Subjectalpha tocopherol; antioxidant; blood and hemopoietic system; drug mechanism; erythrocyte membrane; human; human cell; human experiment; normal human; oral drug administration; plasma; Adult; Antioxidants; Erythrocyte Membrane; Erythrocytes; Human; Lipids; Male; Membrane Lipids; Middle Age; Solubility; Support, Non-U.S. Gov't; Vitamin E
AbstractThe concentrations of lipid-soluble, chain-breaking antioxidants in human plasma and in erythrocyte ghosts have been determined for the first time by an inhibited-autoxidation method. The results are very similar to the concentrations of vitamin E measured for the same blood components by the HPLC method. It is concluded that vitamin E, which is largely present as α-tocopherol, is the only significant lipid-soluble, chain-breaking type of antioxidant present in human blood. The concentration of vitamin E-in the plasma lipids divided by the concentration of vitamin E in the ghost membrane lipids is approximately a constant despite the large differences in vitamin E-intake and in plasma lipid concentrations in different individuals. Vitamin E/lipid ratios for plasma and ghosts were larger for subjects taking a supplement of α-tocopherol acetate of 100 IU per week, compared to nonsupplemented subjects (based on data from a limited number of subjects). A larger supplement of 2800 IU per week did not significantly increase the vitamin E/lipid ratios. © 1983.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276660
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Record identifier0a7de89a-f1b7-40d0-bc76-b377eaecd7ed
Record created2015-10-13
Record modified2016-05-09
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