Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats

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DOIResolve DOI: http://doi.org/10.1016/j.atherosclerosis.2008.03.008
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TypeArticle
Journal titleAtherosclerosis
Volume201
IssueNovember 1
Pages101107; # of pages: 7
SubjectBerberine; Plant stanols; Plasma cholesterol; Plasma triacylglyceride; Liver cholesterol; Toxicity; Rats
AbstractThe objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and plant stanols (PS) on plasma lipid profiles in male Sprague–Dawley rats. Four groups of animals were fed a cornstarch–casein–sucrose-based high-cholesterol (2%, w:w) and high-fat (27.5%) diet. Three treatment groups were supplemented with either BBR (100 mg kg⁻¹ body weight d⁻¹), PS (1% in diet, w:w), or the combination of both (BBRPS). After 6 wk, animals were sacrificed and followed immediately with the collection of blood and organ samples. Lipid analysis revealed that PS lowered plasma total cholesterol (T-C) by 18% (p = 0.067) and non-HDL-cholesterol (non-HDL-C) by 29% (p = 0.013) as compared with the control, while BBR had no effect on both T-C and non-HDL-C. The combination treatment of BBRPS reduced plasma T-C by 41% (p = 0.0002) and non-HDL-C by 59% (p < 0.0001) compared to the control group. BBR reduced plasma TG levels by 31% at a marginal significance relative to the control (p = 0.054), whereas PS had no effect. BBRPS showed an additive effect of BBR and PS on plasma TAG. PS and BBRPS both decreased liver cholesterol (p = 0.0027 and 0.0002, respectively). BBR and PS, either alone or in combination, did not show any toxic effects as assessed by plasma concentration of hepatic biochemical parameters. These results demonstrate that BBR and PS, when combined, synergistically lower plasma cholesterol levels and significantly reduce liver cholesterol, without the observation of any toxic effects.
Publication date
PublisherElsevier
Copyright noticeThe Publisher's version/PDF can be used in NPArC after an embargo period of 12 months form the date of publication. Previous to the embargo to be lifted, NPArC will link to the publisher' site and will continue to do so after embargo has been lifted.
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Nutrisciences and Health
Access conditionavailable
unlimited
public
Peer reviewedYes
NRC number54688
NPARC number9135168
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Record identifier0a90ea0a-c65a-4203-90e6-481c70c535e3
Record created2009-10-03
Record modified2016-05-09
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