The molecular dynamics of cholesterol in bilayer membranes: A deuterium NMR study

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DOIResolve DOI: http://doi.org/10.1016/0009-3084(81)90066-9
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TypeArticle
Journal titleChemistry and Physics of Lipids
ISSN0009-3084
Volume29
Issue4
Pages327339; # of pages: 13
Subjectcholesterol; membrane; 2H-NMR; dynamics
AbstractThe 2H-NMR spectra of selectively deuterated cholesterol, intercalated in egg phosphatidyl-choline, were examined. The orientation of the axis of motional averaging was calculated using the observed quadrupole splittings and the atomic coordinates. With the known orientation of the rotation axis, quadrupole splittings observed for deuterium labels on cholesterol can be related to the molecular order parameter of the sterol. In addition, knowledge of the axis orientation allows prediction of the magnitudes of quadrupole splittings for deuterium at other positions, which is useful in the choice of labelling for particular applications. Finally, preliminary relaxation time measurements yield information on the rates of anisotropic motion of cholesterol in bilayer membranes.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada
Peer reviewedYes
Identifier19787
NPARC number21275082
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Record identifier0b5cd107-15f1-47eb-b3de-d5e38a126eff
Record created2015-05-07
Record modified2016-05-09
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