Enhanced surface plasmon resonance imaging detection of DNA hybridization on periodic gold nanoposts

Download
  1. (PDF, 417 KB)
  2. Get@NRC: Enhanced surface plasmon resonance imaging detection of DNA hybridization on periodic gold nanoposts (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1364/OL.32.003092
AuthorSearch for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleOptics Letters
Volume32
Issue21
Pages30923094; # of pages: 3
AbstractWe explore periodic gold nanoposts as substrates for the enhanced surface plasmon resonance imaging (SPRi) detection of DNA hybridization. Rigorous coupled-wave analysis was used to model and design the nanopost-based SPRi biosensor. Arrayed gold nanoposts on gold-coated glass substrate, with various widths and periodicity, were fabricated using electron-beam lithography and characterized with scanning electron and atomic force microscopy. A scanning-angle SPRi apparatus was used to conduct the kinetic analysis of DNA hybridization on nanopost-based sensor surface and assess the corresponding SPR signal amplification. Experimental results showed that both the nanostructure size and period influenced the SPR signal enhancement; the optimized 30 nm height, 50 nm size, and 110 nm period nanoposts provided a fivefold SPR signal amplification compared with the plain 50 nm thick gold film used as control.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Industrial Materials Institute
Peer reviewedYes
NRC number53678
NPARC number15854994
Export citationExport as RIS
Report a correctionReport a correction
Record identifier0b723396-1f7d-49b1-92b3-aa53ac685cec
Record created2010-07-30
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)