Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum

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DOIResolve DOI: http://doi.org/10.1021/np0401720
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TypeArticle
Journal titleJournal of Natural Products
ISSN0163-3864
1520-6025
Volume68
Issue5
Pages706710; # of pages: 5
AbstractThe CH2Cl2 extract of the seed kernels of Caesalpinia crista, which exhibited promising antimalarial activity against Plasmodium berghei-infected mice in vivo, was examined and resulted in the isolation of seven new furanocassane-type diterpenes [caesalpinins C−G (1−5) and norcaesalpinins D and E (6, 7)] together with norcaesalpinins A−C (8−10) and 11 known compounds (norcaesalpinins A−C, 2-acetoxy-3-deacetoxycaesaldekarin e, caesalmin B, caesaldekarin e, caesalpin F, 14(17)-dehydrocaesalpin F, 2-acetoxycaesaldekarin e, 7-acetoxybonducellpin C, and caesalmin G). Their structures were determined on the basis of spectroscopic analysis. The isolated diterpenes showed significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro. Their IC50 values ranged from 90 nM to 6.5 μM, and norcaesalpinin E (7) showed the most potent inhibitory activity (IC50, 90 nM).
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LanguageEnglish
Peer reviewedYes
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NPARC number21274269
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Record identifier0d116e74-2f3d-46c8-b24e-09eace870463
Record created2015-03-06
Record modified2016-05-09
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