Vertebrate-like regeneration in the invertebrate chordate amphioxus

  1. Get@NRC: Vertebrate-like regeneration in the invertebrate chordate amphioxus (Opens in a new window)
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Journal titleProceedings of the National Academy of Sciences of the United States of America
Pages517522; # of pages: 6
Subjectinvertebrate chordate-vertebrate transition; stem cells; cephalochordate
AbstractAn important question in biology is why some animals are able to regenerate, whereas others are not. The basal chordate amphioxus is uniquely positioned to address the evolution of regeneration. We report here the high regeneration potential of the European amphioxus Branchiostoma lanceolatum. Adults regenerate both anterior and posterior structures, including neural tube, notochord, fin, and muscle. Development of a classifier based on tail regeneration profiles predicts the assignment of young and old adults to their own class with >94% accuracy. The process involves loss of differentiated characteristics, formation of an msx-expressing blastema, and neurogenesis. Moreover, regeneration is linked to the activation of satellite-like Pax3/7 progenitor cells, the extent of which declines with size and age. Our results provide a framework for understanding the evolution and diversity of regeneration mechanisms in vertebrates.
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AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number21269076
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Record identifier0d88d5e5-ac42-461a-82f2-a038a18b8537
Record created2013-12-05
Record modified2016-05-09
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