HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D tranferred NOESY

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DOIResolve DOI: http://doi.org/10.1016/j.bmcl.2004.08.018
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TypeArticle
Journal titleBioorganic & Medicinal Chemistry Letters
Volume14
Issue21
Pages53335337; # of pages: 5
Subjectpha; polymerase-bound; sulfonamide
AbstractHCV NS5B RNA-dependent RNA polymerase (NS5B) is essential for viral replication and is therefore considered a target for antiviral drug development. From our ongoing screening effort in the search for new anti-HCV agents, a novel inhibitor 1 with low lM activity against the HCV NS5B polymerase was identified. SAR analysis indicated the optimal substitution pattern required for activity, for example, carboxylic acid group at 2-position of thiophene ring. We describe the steps taken to identify and solve the bioactive conformation of derivative 6 through the use of the transferred NOE method (trNOE).
Publication date
LanguageEnglish
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedNo
NRC number46236
NPARC number3539714
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Record identifier0d8b0768-2b37-4296-b1de-548dfaaab3c4
Record created2009-03-01
Record modified2016-05-09
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