Effect of sterilization on non-woven polyethylene terephthalate fiber structures for vascular grafts

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DOIResolve DOI: http://doi.org/10.1002/mabi.201000268
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TypeArticle
Journal titleMacromolecular Bioscience
Volume11
Issue1
Pages1321; # of pages: 9
AbstractNon-woven polyethylene terephthalate (PET) fibers produced via melt blowing and compounded into a 6mm diameter 3D tubular scaffold were developed with artery matching mechanical properties. This work compares the effects of ethylene oxide (EtO) and low temperature plasma (LTP) sterilization on PET surface chemistry and biocompatibility. As seen through X-ray photoelectron spectroscopy (XPS) analysis, LTP sterilization led to an increase in overall oxygen content and the creation of new hydroxyl groups. EtO sterilization induced alkylation of the PET polymer. The in vitro cytotoxicity showed similar fibroblastic viability on LTP- and EtOtreated PET fibers. However, TNF-a release levels, indicative of macrophage activation, were significantly higher when macrophages were incubated on EtO-treated PET fibers. Subcutaneous mice implantation revealed an inflammatory response with foreign body reaction to PET grafts independent of the sterilization procedure.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Industrial Materials Institute
Peer reviewedYes
NRC number53862
NPARC number16931679
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Record identifier0e43094e-0cae-4804-8411-2b63c0d930da
Record created2011-03-14
Record modified2016-05-09
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