Leveraging metabolomics to assess the next generation of temozolomide-based therapeutic approaches for glioblastomas

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DOIResolve DOI: http://doi.org/10.1016/j.gpb.2013.04.003
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TypeArticle
Journal titleGenomics, Proteomics and Bioinformatics
ISSN1672-0229
Volume11
Issue4
Pages199206; # of pages: 8
SubjectGlioblastoma multiforme; Temozolomide; Signaling cascades; Cancer therapeutics; Cancer diagnosis
AbstractGlioblastoma multiforme (GBM) is the most common adult primary tumor of the central nervous system. The current standard of care for glioblastoma patients involves a combination of surgery, radiotherapy and chemotherapy with the alkylating agent temozolomide. Several mechanisms underlying the inherent and acquired temozolomide resistance have been identified and contribute to treatment failure. Early identification of temozolomide-resistant GBM patients and improvement of the therapeutic strategies available to treat this malignancy are of uttermost importance. This review initially looks at the molecular pathways underlying GBM formation and development with a particular emphasis placed on recent therapeutic advances made in the field. Our focus will next be directed toward the molecular mechanisms modulating temozolomide resistance in GBM patients and the strategies envisioned to circumvent this resistance. Finally, we highlight the diagnostic and prognostic value of metabolomics in cancers and assess its potential usefulness in improving the current standard of care for GBM patients.
Publication date
LanguageEnglish
AffiliationInformation and Communication Technologies; National Research Council Canada
Peer reviewedYes
NPARC number21270433
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Record identifier0e4d550d-27a8-4b38-b60a-e76cb853870a
Record created2014-02-10
Record modified2016-05-09
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