Low-Temperature approach to highly emissive copper indium sulfide colloidal nanocrystals and their bioimaging applications

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DOIResolve DOI: http://doi.org/10.1021/am302951k
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TypeArticle
Journal titleACS Applied Materials and Interfaces
ISSN1944-8244
Volume5
Issue8
Pages28702880; # of pages: 11
SubjectCuInS2 nanocrystals; quantum dots; diphenylphosphine sulphide; in vitro imaging; in vivo imaging
AbstractWe report our newly developed low-temperature synthesis of colloidal photoluminescent (PL) CuInS2 nanocrystals (NCs) and their in vitro and in vivo imaging applications. With diphenylphosphine sulphide (SDPP) as a S precursor made from elemental S and diphenylphosphine, this is a noninjection based approach in 1-dodecanethiol (DDT) with excellent synthetic reproducibility and large-scale capability. For a typical synthesis with copper iodide (CuI) as a Cu source and indium acetate (In(OAc)3) as an In source, the growth temperature was as low as 160 C and the feed molar ratios were 1Cu-to-1In-to-4S. Amazingly, the resulting CuInS2 NCs in toluene exhibit quantum yield (QY) of ∼23% with photoemission peaking at ∼760 nm and full width at half maximum (FWHM) of ∼140 nm. With a mean size of ∼3.4 nm (measured from the vertices to the bases of the pyramids), they are pyramidal in shape with a crystal structure of tetragonal chalcopyrite. In situ 31P NMR (monitored from 30 C to 100 C) and in situ absorption at 80 C suggested that the Cu precursor should be less reactive toward SDPP than the In precursor. For our in vitro and in vivo imaging applications, CuInS 2/ZnS core-shell QDs were synthesized; afterwards, dihydrolipoic acid (DHLA) or 11-mercaptoundecanoic acid (MUA) were used for ligand exchange and then bio-conjugation was performed. Two single-domain antibodies (sdAbs) were used. One was 2A3 for in vitro imaging of BxPC3 pancreatic cancer cells. The other was EG2 for in vivo imaging of a Glioblastoma U87MG brain tumour model. The bioimaging data illustrate that the CuInS2 NCs from our SDPP-based low-temperature noninjection approach are good quality.
Publication date
PublisherACS Publications
LanguageEnglish
AffiliationSecurity and Disruptive Technologies; NRC Steacie Institute for Molecular Sciences; National Research Council Canada; Human Health Therapeutics; Measurement Science and Standards; Energy, Mining and Environment; Information and Communication Technologies
Peer reviewedYes
NRC numberNRC-HHT-53277
NPARC number21270647
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Record identifier10633ab5-bcb2-48c1-95b0-7e32cbd1efd6
Record created2014-02-17
Record modified2016-05-09
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