Global variation in the genetic and biochemical basis of diamondback moth resistance to Bacillus thuringiensis

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TypeArticle
Journal titleProceedings of the National Academy Sciences of the United States of America
Volume94
Issue24
Pages1278012785; # of pages: 6
AbstractInsecticidal proteins from the soil bacterium Bacillus thuringiensis (Bt) are becoming a cornerstone of ecologically sound pest management. However, if pests quickly adapt, the benefits of environmentally benign Bt toxins in sprays and genetically engineered crops will be short-lived. The diamondback moth (Plutella xylostella) is the first insect to evolve resistance to Bt in open-field populations. Here we report that populations from Hawaii and Pennsylvania share a genetic locus at which a recessive mutation associated with reduced toxin binding confers extremely high resistance to four Bt toxins. In contrast, resistance in a population from the Philippines shows multilocus control, a narrower spectrum, and for some Bt toxins, inheritance that is not recessive and not associated with reduced binding. The observed variation in the genetic and biochemical basis of resistance to Bt, which is unlike patterns documented for some synthetic insecticides, profoundly affects the choice of strategies for combating resistance.
Publication date
Linkhttp://www.pnas.org/content/94/24/12780.abstract
LanguageEnglish
AffiliationNRC Biotechnology Research Institute; National Research Council Canada
Peer reviewedNo
NRC number40511
NPARC number3539145
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Record identifier110a5740-4e5c-4a0a-9dc1-8c40a03a42ad
Record created2009-03-01
Record modified2016-05-09
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