A multiple recording patch clamp chip with integrated subterranean microfluidic channels for cultured neuronal networks

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TypeArticle
Proceedings titleProceedings of the Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences - MicroTAS 2008
ConferenceTwelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, 12-16 October 2008, San Diego, California, USA
ISBN978-0-9798064-1-4
Pages507509; # of pages: 3
AbstractWe report on a new type of patch-clamp chip that can simultaneously monitor electrophysiological activity from several individual neurons grown in simple networks. As in automated patch-clamp chips used for isolated cells in suspension, cells are interrogated using a microhole integrated into a membrane. The novelty of our chip resides in its capacity to position, culture and guide neurons into organized networks over multiple interrogation sites, thereby permitting high resolution monitoring of pre and post synaptic activity in these networks.
Publication date
PublisherRoyal Society of Chemistry
LanguageEnglish
AffiliationNRC Institute for Microstructural Sciences; National Research Council Canada
Peer reviewedNo
NPARC number21262545
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Record identifier1136b426-c31e-47bb-b1db-848cc577953f
Record created2013-03-13
Record modified2016-05-09
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