Magnetic gold nanoparticles: synthesis, characterization and its application in the delivery of FITC into KG-1 cells

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DOIResolve DOI: http://doi.org/10.1166/jnn.2012.6647
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TypeArticle
Journal titleJournal of Nanoscience and Nanotechnology
ISSN1533-4880
Volume12
Issue10
Pages77167722; # of pages: 7
SubjectConfocal imaging; Core shell structure; Iron oxide nanoparticle; Isothiocyanates; Magnetic force; Magnetic nanoparticles; Micropores; Solution treatments; Sonication method; Spherical morphologies; Flow cytometry; Metal nanoparticles; Organic acids; Synthesis (chemical); fluorescein isothiocyanate; atomic force microscopy; confocal microscopy; fluorescence microscopy
AbstractIn this article, we report a new method\-a sonication method to disperse iron oxide nanoparticles into smaller nanoparticles and make gold ions absorb onto the surface or trapped in the micropores of the iron oxide nanoparticles using sonication action. By using quick reduction of ascorbic acid and post-HCl solution treatment, gold covered magnetic nanoparticles (mGNPs) with spherical morphology and uniform size were synthesized in a water solution. The size of the mGNPs was found to be 20-30 nm. Some ideal mGNPs possessed a core-shell structure. The mGNPs were non-cytotoxic and mGNP-fluorescein isothiocyanate (FITC) can enter KG-1 cells when driven by an external magnetic force, which was confirmed by confocal imaging. The confocal image also showed the FITC inside the KG-1 cells was near the nucleus. The fluorescein isothiocyanate (FITC) delivery efficiency is about 100% according to the flow cytometry results.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); Security and Disruptive Technologies
Peer reviewedYes
NPARC number21270229
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Record identifier11c53ebf-4b5b-4e08-a29e-a9652970c616
Record created2014-01-14
Record modified2016-05-09
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