Physicochemical properties of functionalized carbon-based nanomaterials and their toxicity to fishes

Download
  1. Get@NRC: Physicochemical properties of functionalized carbon-based nanomaterials and their toxicity to fishes (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/j.carbon.2016.03.041
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleCarbon
ISSN0008-6223
Volume104
Pages7889
AbstractChemical functionalization to tailor surface properties of nanomaterials (NMs) is expected to broaden their scope of potential applications but may also be used to modify NM toxicity. We have examined the physicochemical properties of single-walled carbon nanotubes (SWCNTs) with varying degrees of carboxylic acid group functionalization, two types of lignin-wrapped SWCNTs, as well as nonfunctionalized SWCNTs. Zebrafish (Danio rerio) embryos were exposed to 1, 10, 50, 100 or 200 mg/L functionalized and nonfunctionalized SWCNTs for up to 72 h; measured endpoints included survival, hatching success, and alteration in gene expression. We have also characterized carboxylated cellulose nanocrystals (CNCs) and examined their effects both in vivo using zebrafish and in vitro using three channel catfish (Ictalurus punctatus) cell lines. While nonfunctionalized SWCNTs did not affect survival or hatch of embryos, carboxylic acid functionalized SWCNTs accelerated hatching and lignin-wrapped SWCNTs both decreased survival and delayed hatch at all time points tested. Carboxylated CNC exposure decreased the viability of 1G8 and 28S.3 catfish cells. We suggest that surface functionality affects SWCNT characteristics and plays a key role in determining their toxicity.
Publication date
PublisherElsevier
LanguageEnglish
AffiliationSecurity and Disruptive Technologies; National Research Council Canada
Peer reviewedYes
IdentifierS0008622316302317
NPARC number23000111
Export citationExport as RIS
Report a correctionReport a correction
Record identifier11c7e634-9a4d-4db7-a468-da7d352a166a
Record created2016-06-03
Record modified2016-06-03
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)