Screening of pancreatic lipase and α-glucosidase inhibitors from Chinese dietary herbs

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DOIResolve DOI: http://doi.org/10.4268/cjcmm20120931
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleChina Journal of Chinese Materia Medica
ISSN1001-5302
Volume37
Issue9
Pages13191323; # of pages: 5
Subjectlipase inhibitor; α-glucosidase inhibitor; Chinese dietary herbs; screening
AbstractThe present study was conducted to develop new inhibitors of pancreatic lipase and α-glucosidase from Chinese dietary herbs. Sixty-three dietary herbs from 39 taxonomic families were selected and extracted with aqueous ethanol or water. The extracts were then tested with in vitro enzyme assays for their ability to inhibit pancreatic lipase and α-glucosidase activities. Orlistat and acarbose were used as two positive controls. The extracts of Nelumbo nucifera, Curcuma longa, Piper longum and Morus alba showed strong pancreatic lipase inhibitory effects with IC50 at (28.00±5.51), (5.24±0.51), (14.76±2.58), (4.78±0.58), (3.41±0.67) mg·L-1, respectively. These extracts also showed potent α-glucosidase inhibitory activities with IC50 at (1.98±0.13), (0.18±0.007), (0.71±0.08), (0.077±0.005), (0.089±0.006) g·L-1, respectively. The results provide useful information for developing new drugs or natural health products for hyperlipidemia and hypoglycemia from Chinese dietary herbs.
Publication date
LanguageEnglish
AffiliationAquatic and Crop Resource Development; NRC Industrial Research Assistance Program; National Research Council Canada
Peer reviewedYes
NPARC number21269132
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Record identifier11c8eb5a-5821-480a-9869-80f2ef79d244
Record created2013-12-09
Record modified2016-05-09
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