Activity-based protein profiling of host–virus interactions

Download
  1. Get@NRC: Activity-based protein profiling of host–virus interactions (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1016/j.tibtech.2011.08.001
AuthorSearch for: ; Search for: ; Search for: ; Search for: ; Search for:
TypeArticle
Journal titleTrends in Biotechnology
ISSN01677799
Volume30
Issue2
Pages8999; # of pages: 11
AbstractVirologists have benefited from large-scale profiling methods to discover new host–virus interactions and to learn about the mechanisms of pathogenesis. One such technique, referred to as activity-based protein profiling (ABPP), uses active site-directed probes to monitor the functional state of enzymes, taking into account post-translational interactions and modifications. ABPP gives insight into the catalytic activity of enzyme families that does not necessarily correlate with protein abundance. ABPP has been used to investigate several viruses and their interactions with their hosts. Differential enzymatic activity induced by viruses has been monitored using ABPP. In this review, we present recent advances and trends involving the use of ABPP methods in understanding host–virus interactions and in identifying novel targets for diagnostic and therapeutic applications.
Publication date
LanguageEnglish
AffiliationNRC Steacie Institute for Molecular Sciences; National Research Council Canada
Peer reviewedYes
IdentifierS0167779911001375
NPARC number21268744
Export citationExport as RIS
Report a correctionReport a correction
Record identifier14548caf-13f1-4fdd-a8b0-32e9cc9430d1
Record created2013-11-12
Record modified2016-05-09
Bookmark and share
  • Share this page with Facebook (Opens in a new window)
  • Share this page with Twitter (Opens in a new window)
  • Share this page with Google+ (Opens in a new window)
  • Share this page with Delicious (Opens in a new window)