N-3 polyunsaturated fatty acids and mast cell activation

  1. Get@NRC: N-3 polyunsaturated fatty acids and mast cell activation (Opens in a new window)
DOIResolve DOI: http://doi.org/10.1189/jlb.2RU0814-388R
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Journal titleJournal of Leukocyte Biology
Pages859871; # of pages: 13
Subjectarachidonic acid; carboxypeptidase A; chymase; docosahexaenoic acid; docosapentaenoic acid; heparin; histamine; icosanoid; icosapentaenoic acid; interleukin 10; interleukin 13; interleukin 17; interleukin 1beta; interleukin 33; interleukin 4; interleukin 5; interleukin 6; interleukin 8; leukotriene B4; leukotriene C4; leukotriene D4; linolenic acid; major basic protein; omega 3 fatty acid; prostaglandin D2; prostaglandin E; serotonin; thrombocyte activating factor; tryptase; tumor necrosis factor; bone marrow derived mast cell; cell activation; cell adhesion; cell migration; cell viability; cytokine production; gene expression; inflammation; lipid raft; mast cell; mast cell degranulation; mediator release; phagocytosis; signal transduction
AbstractMast cells are known to play a vital role in the development of inflammation in allergic responses. Recent studies have indicated that mast cell activation could be modulated by n-3 PUFAs, which have a wide range of well-documented health benefits. In our review, we summarize the recent findings and potential mechanisms of the effect of n-3 PUFAs on mast cell activation. This knowledge could provide new strategies for the development of therapeutic interventions for diseases mediated by mast cells.
Publication date
PublisherThe Society for Leukocyte Biology
AffiliationNational Research Council Canada (NRC-CNRC); National Institute for Nanotechnology
Peer reviewedYes
NPARC number21275622
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Record identifier14c05523-1e2f-4ac3-964a-824723df7e05
Record created2015-07-14
Record modified2016-05-09
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