Reagent-based, modular, tandem Michael approach for obtaining different indoline alkaloid-inspired polycyclic architectures

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DOIResolve DOI: http://doi.org/10.1021/cc800036w
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TypeArticle
Journal titleJournal of Combinatorial Chemistry
ISSN1520-4766
Volume10
Issue3
Pages405420; # of pages: 16
AbstractA modular, reagent-based approach to obtain different indoline alkaloid-inspired, tetracyclic architectures is developed. With the use of TBSOTf as a Lewis acid, we report here a tandem Michael-based approach that led to the synthesis of a diastereomeric mixture of tetracyclic derivatives with two additional six-membered rings. By simply changing the Lewis acid to TMSOTf, we were able to obtain a different tetracyclic compound having additional functionalized 5- and 7-membered rings with complete stereocontrol.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier18517171
NPARC number12328691
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Record identifier166e492e-4da0-4299-8413-384b3ee8621f
Record created2009-09-10
Record modified2016-05-09
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