Enhancement of biological mass spectrometry by using separations based on changes in ion mobility (FAIMS and DMS)

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DOIResolve DOI: http://doi.org/10.1007/s00216-012-6496-3
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TypeArticle
Journal titleAnalytical and Bioanalytical Chemistry
ISSN1618-2642
1618-2650
Volume405
Issue1
Pages3542; # of pages: 8
SubjectBioanalytical methods; biological samples; HPLC; mass spectrometry; FAIMS; DMS
AbstractAnalysis of complex biological samples for lowlevel analytes by liquid chromatography–tandem mass spectrometry (LC–MS/MS) often requires additional selectivity. Differential mobility techniques (FAIMS and DMS) have been shown to enhance LC–MS/MS analyses by separating ions in the gas-phase on a millisecond timescale by use of a mechanism that is complementary to both liquid chromatography and mass spectrometry. In this overview, a simplified description of the operation of these devices is given and an example presented that illustrates the utility of FAIMS (DMS) for solving a challenging analytical assay. Important recent advances in the field, including work with gas modifiers, are presented, along with an outlook for the technology.
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PublisherSpringer
LanguageEnglish
AffiliationNational Research Council Canada; Aquatic and Crop Resource Development
Peer reviewedYes
NRC number54665
NPARC number21268465
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Record identifier16d202cb-49d8-416b-8715-53a45478a6ae
Record created2013-07-24
Record modified2016-05-09
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