Non-contact photoacoustic tomography and ultrasonography for tissue imaging

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Journal titleBiomedical Optics Express
Pages1625; # of pages: 10
SubjectBiological tissues; Biomedical imaging; Chicken breast; Confocal Fabry Perot interferometer; Differential configuration; Ex-vivo; Laser exposure; Laser ultrasonics; Non-contact; Optical detection; Photoacoustic tomography; Potential applications; Safety limits; Scope of application; Shaped laser pulse; Small animal imaging; Tissue imaging; Animals; Bioacoustics; Laser safety; Medical imaging; Tissue; Ultrasonic applications; Ultrasonic transducers; Ultrasonics; Ultrasonography; Photoacoustic effect; Animalia; Columba
AbstractThe detection of ultrasound in photoacoustic tomography (PAT) and ultrasonography (US) usually relies on ultrasonic transducers in contact with the biological tissue. This is a major drawback for important potential applications such as surgery and small animal imaging. Here we report the use of remote optical detection, as used in industrial laser-ultrasonics, to detect ultrasound in biological tissues. This strategy enables non-contact implementation of PAT and US without exceeding laser exposure safety limits. The method uses suitably shaped laser pulses and a confocal Fabry-Perot interferometer in differential configuration to reach quantum-limited sensitivity. Endogenous and exogenous inclusions exhibiting optical and acoustic contrasts were detected ex vivo in chicken breast and calf brain specimens. Inclusions down to 0.5 mm in size were detected at depths well exceeding 1 cm. The method could significantly expand the scope of applications of PAT and US in biomedical imaging. © 2011 Optical Society of America.
Publication date
AffiliationNational Research Council Canada (NRC-CNRC); NRC Industrial Materials Institute (IMI-IMI)
Peer reviewedYes
NPARC number21269483
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Record identifier1c6888d7-f239-4978-8996-2ce57068dd04
Record created2013-12-12
Record modified2016-05-09
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