Copper-catalysed cycloaddition reactions of nitrones and alkynes for bioorthogonal labelling of living cells

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DOIResolve DOI: http://doi.org/10.1039/c4ra07851a
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TypeArticle
Journal titleRSC Advances
ISSN2046-2069
Volume4
Issue87
Pages4696646969; # of pages: 4
SubjectBioorthogonal labelling; Cycloaddition reaction; Living cell; Nitrones
AbstractAn adapted biocompatible version of the Kinugasa reaction, the copper-catalysed alkyne-nitrone cycloaddition followed by rearrangement (CuANCR), was developed for live-cell labelling. CuANCR labelling was demonstrated for both mammalian and bacterial cells. A method for metabolic incorporation of the nitrone group is also described. This journal is
Publication date
PublisherRoyal Society of Chemistry
LanguageEnglish
AffiliationMedical Devices; National Research Council Canada
Peer reviewedYes
NPARC number21272856
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Record identifier1cc5bfa9-378c-4370-91e6-7f7b11e24d07
Record created2014-12-03
Record modified2016-05-09
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