A novel introduction system for hydride generation-inductively coupled plasma mass spectrometry: determination of selenium in biological materials

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DOIResolve DOI: http://doi.org/10.1039/a909296j
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TypeArticle
Journal titleJournal of Analytical Atomic Spectrometry
ISSN0267-9477
Volume15
Issue2
Pages143149; # of pages: 7
AbstractA novel, robust hydride generation system compatible with sample introduction with inductively coupled plasma mass spectrometry is described and applied to the determination of Se in biological tissues. A short reaction time (60 ms) and a rapid separation of the reaction products is obtained by mixing the acidified sample and the sodium borohydride reductant solution at the tip of a cross-flow nebuliser. A modified Scott spray chamber serves as a gas–liquid separator, providing 30 s wash-in and wash-out times. Analytical results generated by external calibration and isotope dilution methodologies agree well with the certified values for Se in certified biological reference materials DORM-2 and DOLT-2. Detection limits for Se and other hydride forming elements, i.e., As, Sn and Sb, are below 10 ng l−1 with typical precision of 2% RSD at the 10 ng ml−1 level. Volatile species of Cu, Rh, Pd, Ag, In, Au, Hg, Tl and Pb are also produced, and estimated sensitivities and detection limits for these elements are reported.
Publication date
LanguageEnglish
AffiliationNRC Institute for National Measurement Standards; National Research Council Canada
Peer reviewedNo
Identifier10391186
NRC number659
NPARC number8896337
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Record identifier1cf25e4d-3d56-4d46-b8dd-1fb3f7206ba1
Record created2009-04-22
Record modified2016-05-09
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