Lipopolysaccharide structure of Helicobacter pylori serogroup O:3

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DOIResolve DOI: http://doi.org/10.1016/j.carres.2013.03.008
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TypeArticle
Journal titleCarbohydrate Research
ISSN0008-6215
Volume378
Pages139143
SubjectHelicobacter pylori; LPS; Structure; NMR; MS
AbstractIn this study, we describe a re-investigation of the lipopolysaccharide structure of Helicobacter pylori serogroup O:3. Application of NMR and MS approaches to the analysis of oligosaccharides obtained through degradation of LPS from H. pylori serogroup O:3 by various methods confirmed that its general architecture was identical to that of LPS from H. pylori strains 26695 and SS1 and followed a sequential linear assembly of the α-1,6-glucan, dd-heptan, and O-chain components. Additionally, MALDI-MS analysis demonstrated that a significant proportion of H. pylori serogroup O:3 LPS was terminated with α-1,6-glucan and was not further substituted by dd-heptan and the O-chain polysaccharide.
Publication date
PublisherElsevier
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
IdentifierS0008621513000876
NPARC number23000553
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Record identifier1d9d8173-a6e0-4886-a6c5-88d24cb99837
Record created2016-07-29
Record modified2016-07-29
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