Comparison of T₂ and T₂ *-weighted MR molecular imaging of a mouse model of glioma

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DOIResolve DOI: http://doi.org/10.1186/1471-2342-13-20
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TypeArticle
Journal titleBMC Medical Imaging
ISSN1471-2342
Volume13
Issue1
Article number20
Pages18
SubjectContrast-to-noise ratio; MRI; Molecular MRI; Contrast agents; Glioma
AbstractBACKGROUND Standard MRI has been used for high-grade gliomas detection, albeit with limited success as it does not provide sufficient specificity and sensitivity to detect complex tumor structure. Therefore targeted contrast agents based on iron oxide, that shorten mostly T2 relaxation time, have been recently applied. However pulse sequences for molecular imaging in animal models of gliomas have not been yet fully studied. The aim of this study was therefore to compare contrast-to-noise ratio (CNR) and explain its origin using spin-echo (SE), gradient echo (GE), GE with flow compensation (GEFC) as well as susceptibility weighted imaging (SWI) in T2 and T2* contrast-enhanced molecular MRI of glioma. METHODS A mouse model was used. U87MGdEGFRvIII cells (U87MG), derived from a human tumor, were injected intracerebrally. A 9.4 T MRI system was used and MR imaging was performed on the 10 day after the inoculation of the tumor. The CNR was measured prior, 20 min, 2 hrs and 24 hrs post intravenous tail administration of glioma targeted paramagnetic nanoparticles (NPs) using SE, SWI, GE and GEFC pulse sequences. RESULTS The results showed significant differences in CNR among all pulse sequences prior injection. GEFC provided higher CNR post contrast agent injection when compared to GE and SE. Post injection CNR was the highest with SWI and significantly different from any other pulse sequence. CONCLUSIONS Molecular MR imaging using targeted contrast agents can enhance the detection of glioma cells at 9.4 T if the optimal pulse sequence is used. Hence, the use of flow compensated pulse sequences, beside SWI, should to be considered in the molecular imaging studies.
Publication date
PublisherBioMed Central
LanguageEnglish
Peer reviewedYes
Identifier185
NPARC number23000491
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Record identifier1df43221-7f4b-4f0e-aa6b-f087d5baf0b2
Record created2016-07-25
Record modified2016-07-25
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