Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1

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DOIResolve DOI: http://doi.org/10.1038/bjc.2011.427
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TypeArticle
Journal titleBritish Journal of Cancer
Volume105
Issue11
Pages16971707; # of pages: 11
Subjectbrain cancer; cancer phenotype; Angiopep-2; blood–brain barrier; low-density lipoprotein receptor-related protein 1 (LRP1)
AbstractANG1005 consists of three molecules of paclitaxel conjugated via ester bonds to the 19-amino-acid peptide Angiopep-2. The new chemical agent has been shown to cross the blood–brain barrier (BBB) by receptor-mediated transcytosis via low-density lipoprotein receptor-related protein 1 (LRP1). The experiments here examined the role of LRP1 in the subsequent endocytosis of drug into cancer cells.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number19254218
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Record identifier1e9d211b-2982-49ac-864f-b435058f38b8
Record created2012-03-08
Record modified2016-05-09
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