Superoxide, amine buffers and tetranitromethane: A novel free radical chain reaction

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DOIResolve DOI: http://doi.org/10.1080/10715760000301081
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TypeArticle
Journal titleFree Radical Research
ISSN1071-5762
Volume33
Issue5
Pages547550; # of pages: 4
Subjectamine; free radical; superoxide; tetranitromethane; aqueous solution; article; chemical reaction; chemical structure; oxidative stress; pH; reaction analysis; Amines; Buffers; Free Radicals; HEPES; Morpholines; Oxidation-Reduction; Superoxides; Tetranitromethane
AbstractThe amine buffer Tris slowly reduces tetranitromethane (TNM) to the nitroform anion in a non-accelerating reaction. The amine buffers HEPES and MOPS also (slowly) react with TNM but the dialkylaminoalkyl radicals formed from these two buffers undergo further reactions resulting in a rapid, accelerating, free radical chain process whereby the amine is oxidized and TNM reduced. The chemical functionality in any reaction component, not necessarily the buffer, required for this radical chain mechanism is >N-CH<. In the presence of such groups, the quantification of superoxide by TNM is impossible.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC)
Peer reviewedYes
NPARC number21276779
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Record identifier22411902-b736-4ae1-a1c5-6c08bce26bef
Record created2015-10-13
Record modified2016-05-09
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