Cellular Lipid Metabolism Is Influenced by the Coordination Environment of Copper

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DOIResolve DOI: http://doi.org/10.1021/ja809451w
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TypeArticle
Journal titleJournal of the American Chemical Society
Volume131
Issue7
Pages24442445; # of pages: 2
Subjectcopper; diseases; alzheimer's; menkes'; microscopy; lipid phenotype; hepatic cells
AbstractCopper ions are vital to human health, and mis-trafficking of them can result in many diseases including Wilson’s, Menkes’, and Alzheimer’s diseases. Coherent anti-Stokes Raman scattering (CARS) microscopy can be used to observe changes in lipid phenotype in a noninvasive manner and is employed here to show that copper accumulation in hepatic cells results in rapid changes in lipid storage and lipid droplet density. The increase in lipid storage is dependent on the coordination environment of the copper to which the cells are exposed and changes in toxicity, lipid phenotype, and rate of copper accumulation upon treatment vary using different Cu species
Publication date
LanguageEnglish
AffiliationNational Research Council Canada (NRC-CNRC); NRC Steacie Institute for Molecular Sciences
Peer reviewedYes
NPARC number16080419
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Record identifier225a6166-a594-4313-af80-d26e669e2c4a
Record created2010-09-21
Record modified2016-05-09
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