Microfluidic control of adipose-derived stem cell growth and positioning

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Proceedings titleNanotechnology 2012: Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo. Volume 2: Electronics, devices, fabrication, MEMS, fluidics and computational.
ConferenceNanotech Conference and Expo 2012, June 18-21, 2012, Santa Clara, CA, USA
Pages306309; # of pages: 4
SubjectAdipose derived stem cells; Cell migration; Chemical factors; Conventional methods; Direct current electric fields; EGF; Epidermal growth factors; Micro-fluidic devices; Microfluidic control; Physical parameters; Stem cell research; Cell growth; Electric fields; Exhibitions; Fabrication; Fluidic devices; Growth kinetics; Nanotechnology; Stem cells; Microfluidics
AbstractMicrofluidic devices provide powerful new tools for quantitative stem cell research owing to its advantages in cellular microenvironmental control and experiment throughput over conventional methods. Particularly, microfluidics is playing a growing role in studying stem cell growth, differentiation and trafficking mediated by chemical factors such as different growth and differentiation factors and physical parameters such as direct current electric fields (dcEF). In the present study, we focused on adipose-derived stem cells (ADSCs) and we quantitatively characterized ADSCs growth and positioning mediated by epidermal growth factor (EGF) and dcEF using microfluidic devices. Our results revealed mat ADSCs preferentially grow toward the EGF gradient. In addition, we showed that ADSCs tend to orient perpendicularly to the dcEF. These microfluidics-based results demonstrated the interesting roles of EGF and dcEF in controlling ADSCs growth and trafficking.
Publication date
AffiliationNational Research Council Canada (NRC-CNRC); Medical Devices
Peer reviewedYes
NPARC number21269156
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Record identifier2310775d-48e9-431f-9b57-4c2280b648f1
Record created2013-12-12
Record modified2016-05-09
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