Stereoselective Diversity-Oriented Solution and Solid-Phase Synthesis of Tetrahydroquinoline-Based Polycyclic Derivatives

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DOIResolve DOI: http://doi.org/10.1021/cc034053z
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TypeArticle
Journal titleJ. Comb. Chem
Volume6
Issue1
Pages5464; # of pages: 11
AbstractA diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based tricyclic derivatives has been achieved from enantiomerically pure, natural product-like bicyclic scaffold. The solution synthesis of enantiopure bicyclic scaffold was developed by asymmetric hetero Michael reaction. Our approach for the synthesis of polycyclic derivatives utilized regio- and stereoselective hetero Michael reaction and ringclosing metathesis as key steps in solution and on solid phase.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; NRC Steacie Institute for Molecular Sciences
Peer reviewedNo
Identifier18517171
NPARC number12340991
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Record identifier2328ce74-557c-41eb-a8b7-179efca0a9fc
Record created2009-09-11
Record modified2016-05-09
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