Quantitative radiolabeled biomolecule detection using a functionalized CMOS sensor

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DOIResolve DOI: http://doi.org/10.1109/NSSMIC.2012.6551473
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TypeArticle
Proceedings titleNuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2012 IEEE
IEEE Nuclear Science Symposium conference record
Conference2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, NSS/MIC 2012, October 29 - November 3, 2012, Anaheim, CA, USA
ISSN1095-7863
ISBN9781467320306
9781467320290
1467320293
Article number6551473
Pages20482052; # of pages: 5
SubjectAptamers; Biomolecule detection; CMOS imagers; Geant4; Radiolabel; Adenosinetriphosphate; CMOS integrated circuits; Detectors; Fluorescence; Medical imaging; Nuclear physics; Radioactive tracers; Biomolecules
AbstractFor the first time a CMOS imager has been used to detect the presence of radiolabeled target biomolecules captured on a functionalized surface. Using aptamer functionalization the system successfully detected 32P labeled adenosine triphosphate (ATP) at concentrations well below those typically associated with fluorescence-based sensor architectures. The system has also demonstrated its amenability to multiplexed biomolecule detection. Geant4, a Monte Carlo toolkit for simulating the passage of radiation through matter, was used to analyze the detector. Radiolabel detection offers the potential for direct quantitative measurement of bound biomolecules which is advantageous compared to the use of fluorescent tags. © 2012 IEEE.
Publication date
LanguageEnglish
AffiliationNational Research Council Canada; Information and Communication Technologies; Security and Disruptive Technologies; Measurement Science and Standards
Peer reviewedYes
NPARC number21270082
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Record identifier23961491-97af-4d9b-afb7-19f188a8951a
Record created2013-12-19
Record modified2016-11-29
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