3',5'-Cyclic diguanylic acid : A small nucleotide that makes big impacts

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DOIResolve DOI: http://doi.org/10.1039/b914942m
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TypeArticle
Journal titleChemical Society Reviews
Volume39
Issue8
Pages29142924; # of pages: 11
Abstract3',5'-Cyclic diguanylic acid (c-di-GMP) is a naturally occurring small cyclic dinucleotide found in bacteria. There has been a recent surge of interest in the two-component signalling networks involving this molecule. This tutorial review introduces the biosynthesis of c-di-GMP, particularly the conserved domain features involved in its enzymatic synthesis and degradation, cellular functions and phenotypes regulated by c-di-GMP through c-di-GMP-binding proteins. The chemical synthesis and structural studies of c-di-GMP are also summarized. Two potential applications of c-di-GMP, i.e. bacterial biofilm formation and immunostimulation, are surveyed. Recent observations on c-di-GMP-binding riboswitches are also introduced.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biological Sciences; National Research Council Canada
Peer reviewedYes
NPARC number17652980
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Record identifier25377ef3-4a0f-42d6-a9a6-df995d8d4da9
Record created2011-04-01
Record modified2016-05-09
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