An efficient spiral microchannel for continuous small particle separations

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DOIResolve DOI: http://doi.org/10.1016/j.snb.2017.06.037
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TypeArticle
Journal titleSensors and Actuators B: Chemical
ISSN0925-4005
Volume252
Pages606615
Subjectparticle separation; microfluidics; inertial focusing; dean vortices; lift force; sample preparation
AbstractWe report a new two-step microfluidic device that performs efficient, continuous, and high throughput small particle separation. The separation mechanism is based the on combined effects of inertial focusing in a spiral microchannel followed by particle deflection in a straight microchannel. The particle trajectory was studied using 1 and 5.5 μm fluorescent polystyrene microbeads as model particles to be separated. We demonstrate that at the condition of 0.4 ml/min inlet, 0.15 ml/min acting, and 0.02 ml/min protecting flow rates, the separation efficiencies of 1 μm particles and 5.5 μm particles were 99.7% and 98.3%, and the corresponding purities were 95.7% and 99.6%, respectively. This new design shows a significant separation performance for small particles, and therefore can be potentially integrated as a promising tool to separate rare of-interest particles, such as bacteria from homogenized food matrix as part of sample preparation procedure for food safety inspections.
Publication date
PublisherElsevier
LanguageEnglish
AffiliationNRC Institute for Microstructural Sciences; National Research Council Canada
Peer reviewedYes
NPARC number23002598
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Record identifier26128a0d-a26e-42a6-a775-99aaab5e5983
Record created2017-12-05
Record modified2017-12-05
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