Challenges and opportunities for bacterial vaccine development in the 21st Century

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DOIResolve DOI: http://doi.org/10.2174/13892010113146660230
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TypeArticle
Journal titleCurrent Pharmaceutical Biotechnology
ISSN1389-2010
Volume14
Issue8
Pages758767
SubjectBacterial diseases; Genomics; Immunomics; Mathematical biology; Proteomics; Vaccinology
AbstractWith the convergence of modern technology in genomics, proteomics, carbohydrate, protein and lipid biochemistry as well as decades of experience in vaccine development and delivery of immunization programs, the Global Vaccine Action Plan has declared 2011 to 2020 as 'The Decade of Vaccines'. This review focuses on bacterial vaccines and summarises the current state of vaccinology in bacteriology and looks forward to the potential of how the newer technologies can impact our knowledge of bacterial diseases and their control through vaccine development. The major breakthroughs in the last couple of decades include low cost high throughput genomics, proteomics, cellular immunology and the delicate network of immune-cytokines, bioinformatics, immune-informatics, and disease modelling. Together, these newer developments can provide a real impact on our understanding of infectious diseases and their control by vaccination.
Publication date
PublisherBentham Science Publishers
LanguageEnglish
AffiliationHuman Health Therapeutics; National Research Council Canada
Peer reviewedYes
IdentifierLiveAll1
NPARC number23000484
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Record identifier28a31833-5724-4b2b-bc44-e623f99c3431
Record created2016-07-25
Record modified2016-07-25
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