A near infrared spectroscopic approach to assess tissue viability following a thermal injury

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DOIResolve DOI: http://doi.org/10.1117/12.432478
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TypeBook Chapter
Proceedings titleBiomarkers and Biological Spectral Imaging
Series titleProceedings of SPIE; no. 4259
ConferenceBiomarkers and Biological Spectral Imaging, January 20, 2001, San Jose, CA, USA
ISSN0277-786X
Pages3646; # of pages: 11
Subjectnear infrared; spectroscopy; cutaneous burns; multivariate analysis
AbstractA recurrent problem in the assessment of thermal injuries is the ability to accurately identify the depth and extent of injury. Generally, the depth of a burn injury determines and is inversely related to the ability of the skin to restore and regenerate itself. Burns involve damage to the dermis in varying amounts, reducing the dermal blood supply and altering the skin hemodynamics. Near infrared spectroscopic imaging was used to non-invasively assess the changes that occur in the early (1-3 h) post-burn period. The study used an accurate porcine model to investigate the potential of near infrared spectroscopic imaging to accurately distinguish between burns of varying severity. Data analysis was carried out using a two-way and three-way data decompositions techniques to investigate the spectral changes related to burns. Burn injuries drastically alter the physical and optical properties of the tissue. Thermal destruction of cutaneous vasculature disrupts perfusion and oxygen delivery to the affected tissue. The results demonstrated that near infrared spectroscopic imaging might provide a new tool for an objective clinical assessment of burn injuries.
Publication date
PublisherSPIE
LanguageEnglish
AffiliationNational Research Council Canada; NRC Institute for Biodiagnostics
Peer reviewedYes
NRC number1878
NPARC number9742065
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Record identifier2983331c-c518-4b81-a746-d6dc39ac1235
Record created2009-07-17
Record modified2017-09-13
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