Chiral high performance liquid chromotography resolution of ibuprofen esters

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DOIResolve DOI: http://doi.org/10.1016/S0731-7085(97)00212-4
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TypeArticle
Journal titleJournal of Pharmaceutical and Biomedical Analysis
Volume16
Issue7
Pages12251231; # of pages: 7
AbstractTwo cellulose-based chiral stationary phases (Chiralcel OD and Chiralcel OJ) were compared on their ability to resolve various aliphatic ibuprofen esters. Chiralcel OJ with hexane as the mobile phase allows for the separation of most of the esters. Observed changes in resolution depending on the solute nature (basicity of the solute, esterified alcohol chain length, presence of a double bond) are discussed. An example of the application of this method for following the kinetic resolution of racemic ibuprofen is presented.
Publication date
AffiliationNational Research Council Canada; NRC Biotechnology Research Institute
Peer reviewedNo
NPARC number12328538
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Record identifier29c0629e-c125-4977-b78e-bfc7a9763e50
Record created2009-09-10
Record modified2016-05-09
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