Spatial MEG Laterality maps for language : clinical applications in epilepsy

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DOIResolve DOI: http://doi.org/10.1002/hbm.22024
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TypeArticle
Journal titleHuman Brain Mapping
ISSN1065-9471
Volume34
Issue8
Pages17491760; # of pages: 12
Subjectmagnetoencephalography; Wada test; presurgical functional mapping; neurological planning; language;memory; cognition
AbstractFunctional imaging is increasingly being used to provide a noninvasive alternative to intracarotid sodium amobarbitol testing (i.e., the Wada test). Although magnetoencephalography (MEG) has shown significant potential in this regard, the resultant output is often reduced to a simplified estimate of laterality. Such estimates belie the richness of functional imaging data and consequently limit the potential value. We present a novel approach that utilizes MEG data to compute “complex laterality vectors” and consequently “laterality maps” for a given function. Language function was examined in healthy controls and in people with epilepsy. When compared with traditional laterality index (LI) approaches, the resultant maps provided critical information about the magnitude and spatial characteristics of lateralized function. Specifically, it was possible to more clearly define low LI scores resulting from strong bilateral activation, high LI scores resulting from weak unilateral activation, and most importantly, the spatial distribution of lateralized activation. We argue that the laterality concept is better presented with the inherent spatial sensitivity of activation maps, rather than being collapsed into a one-dimensional index.
Publication date
LanguageEnglish
AffiliationNRC Institute for Biodiagnostics; National Research Council Canada
Peer reviewedYes
NPARC number21268346
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Record identifier29e903e6-b0e1-430b-8f96-82a83ef6126e
Record created2013-06-28
Record modified2016-05-09
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