Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters

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DOIResolve DOI: http://doi.org/10.1007/s11745-003-1047-3
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TypeArticle
Journal titleLipids
ISSN0024-4201
1558-9307
Volume38
Issue2
Pages165170
AbstractThe current study was carried out to examine the effects of policosanols and phytosterols, alone and in combination, on lipid profiles, cholesterol biosynthesis, and tissue histopathological changes in hamsters. Fifty male Golden Syrian hamsters, weighing 100 to 120 g, were fed a regular rodent chow for 2 wk before being randomly assigned into 5 groups of 10 animals each fed semisynthetic diets for 4 wk. Group 1 was given a control diet that contained 0.25% cholesterol and 5% fat with a PUFA to saturated FA ratio of 0.4. Groups 2 to 5 were fed the control diet and given Octa-6 [a policosanol mixture from sugar cane was, 25 mg/kg body weight (BW)], Ricewax (a policosanol mixture from rice wax with 50% being converted to the corresponding acids, 50 mg/kg BW), phytosterols (CholestatinTM; 1,000 mg/kg BW), and Ricewax (50 mg/kg BW) plus phytosterols (1,000 mg/kg BW), respectively. The results showed that there was no difference between Octa-6 and Ricewax treatments in any of the lipid parameters measured, and both had similar levels of triglyceride (TG), total cholesterol (T-C), and HDL cholesterol (HDL-C) as the control. Octa-6 but not Ricewax increased (P=0.03) non-HDL-C as compared with the control. Phytosterols reduced T-C (P<0.0003) and HDL-C (P<0.004) without a significant effect on TG and non-HDL-C as compared to the control. Ricewax plus phytosterols had effects similar to those with phytosterols alone. Free cholesterol synthetic rates were not different among the treatments. Policosanols or phytosterols did not show any toxic effects in liver, heart, brain, or kidney. Results suggest that, although phytosterols reduce T-C and HDL-C levels, policosanols have no significant favorable effect in changing lipid levels in hamsters.
Publication date
PublisherSpringer
LanguageEnglish
AffiliationNational Research Council Canada
Peer reviewedYes
NPARC number23001740
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Record identifier2a1aa8c2-08fc-4059-87d2-33cddece37dd
Record created2017-03-27
Record modified2017-03-27
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